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THE MEDICAL PROPERTIES OF CBD
Cannabidiol is often considered the star of the medical marijuana show as recent research shows it has many potential medicinal benefits.
Below we take an in-depth look at how CBD may help in the treatment of seizures and convulsions produced by epilepsy. We’ll also take a brief look at how this cannabinoid may also aid in the treatment of pain, anxiety, and nausea.
CBD IN TREATING EPILEPSY
Cannabidiol first made headlines a few years ago as a possible treatment for refractory epilepsy.
In 2013, the story of Charlotte Figi left people across the world stunned.
Charlotte was born in 2006 and suffers from Dravet syndrome, a severe kind of epilepsy that leaves her suffering up to 400 seizures per week. Each seizure can last over 30 minutes.
Charlottes parents and doctors began treating Charlotte with a CBD rich extract (now known as Charlotte’s Web) made by a group of cannabis cultivators in Colorado, USA, known as the Stanley Brothers. In her first week of treatment, Charlotte experienced no seizures at all.
Charlotte’s story isn’t unique; since she made headlines in 2013, thousands of others suffering from similar conditions have come forward with stories of successfully treating their symptoms with CBD-rich cannabis extracts like Charlotte’s Web.
But the evidence for CBD as an anticonvulsant isn’t just anecdotal. One of the most significant studies of CBD as a treatment for epilepsy was published in The Lancet in 2015.
Orrin Devinsky, a neurologist at New York University Langone Medical Center and his colleagues enrolled 214 patients who all suffered from Dravet syndrome, Lennox-Gastaut syndrome, or other kinds of refractory epilepsy.
Patients were treated with a 99% CBD extract and monitored for 12 weeks. The patients received the CBD extract along with their regular medications and the test was open-label, meaning everyone knew what they were getting.
The study found that the CBD extract reduced motor seizures by 36.5%, while 2% of patients became completely seizure free. However, it also noted that 79% of the patients experienced side effects due to using the extract, which we will explore in more detail below.
Given these results, Devinsky and his team of researchers concluded that CBD may help to reduce the frequency of seizures in people with highly treatment-resistant epilepsy. It also concluded that the cannabinoid may be safe enough to be used on children and young adults, but needs to be studied further to confirm these claims.
Others studies have produced similar results. In 2016, for example, an Israeli study (published in Seizure, the journal of the British Epilepsy Association) looked at the effect of CBD on children of up to 18 years suffering from difficult to treat epilepsy.
The study included 74 patients (aged 1-18 years) with cases of epilepsy that were resistant to 7 or more antiepileptic drugs. The patients were treated using with an extract of CB:THC of 20:1 for at least 3 months. The frequency of seizures was reported by the parents of the patients during clinical visits.
The study found that 89% of the children experienced a significant reduction in seizures, with 18% noticing a decrease in seizures of between 75 and 100%. 5% of patients noted aggravated seizures.
The researchers concluded that CBD is a promising treatment alternative for children suffering from refractory epilepsy and should be studied further.
CBD FOR PAIN RELIEF
Research suggests that CBD may help to relieve pain by inhibiting the transmission of pain signals in our body. A 2012 study published in the Journal of Experimental Medicine found that CBD suppressed inflammatory and neuropathic pain in rodents without building u-p tolerance.
A 2007 meta-analysis also found that Sativex, a popular mouth spray containing an almost 1:1 ratio of CBD and THC, reduced neuropathic pain in patients suffering from multiple sclerosis. These results suggest that CBD may play an important role in managing pain associated with a variety of conditions, such as arthritis, fibromyalgia, or even cancer.
CBD is often considered the cannabinoid that helped legitimize medical cannabis. But what exactly is CBD? How is it produced and just how useful is it as a medicine?
CBD, or cannabidiol, is one of at least 113 cannabinoids found in cannabis. Like other cannabinoids, CBD interacts with our body’s endocannabinoid system (or ECS) whenever we consume cannabis or a cannabis product such as an edible or concentrate.
The endocannabinoid consist of two key receptors (CB1 and CB2) and plays a key role in mediating a variety of physiological processes, including appetite, memory, pain-sensation, mood, and more.
The ECS is also capable of producing its own cannabinoids, such as anandamide, which is produced after exercise and believed to cause “runner’s high.”
CBD, unlike THC (or tetrahydrocannabinol) is a non-psychoactive cannabinoid, meaning it doesn’t produce a “high.” It is the second most common cannabinoid found in cannabis and usually found in higher concentration in hemp plants cannabis sativa L), which naturally contain lower concentrations of THC.
The oil produced by alcohol extraction and purification with petroleum ether contains tetrahydrocannabinol, two other compounds closely related to THC but non-psychoactive (cannabidiol and cannabinol), and several other compounds which contribute the taste and smell of the oil. The quality and quantity of the THC in the oil is determined by the quality and potency of the starting material. The oil from very strong cannabis material contains a much higher percentage of THC than the oil from marijuana or hashish that is less potent. The quality of the THC and the characteristics of the effect (high) are determined by the relative positions of the double bonding in the THC molecule. The higher-rotating forms are more potent the low-rotating and produce a higher, more psychedelic and spiritual effect. Methods for convert. THC from low- to high-rotating follow.
The quantity of cannabidiol in the oil is important as it may be converted to THC, thereby increasing the potency of the oil proportionally. Experience has indicated that the quantity of cannabidiol is usually least equal to the quantity of THC. Because of this, the strength of the oil can be at least doubled through Isomerization, and in some cases potency may be creased five to six times.
By using the correct chemicals and methods convert the cannabidiol to THC, it is possible simultaneously to convert the THC (that which occurs naturally in the oil and also that which has been produced from cannabidiol) to higher-rotating forms.
The highest benefit is obtained by starting with material high in cannabidiol, isomerizing the cannabidiol to THC, and converting the THC to its higher rotating form. Both the potency of the oil and the quality of the high are greatly increased. The operation is carried out as follows:
The oil from the ether extraction is dissolved in absolute ethanol or pure methanol in the ratio of one gram of oil to ten grams of solvent. The ethanol may be denatured, but must not contain water. One drop of 100 per cent sulfuric acid is added to the alcohol/oil
solution for each gram of oil. The acid is added slowly with continuous stirring. Pure sulfuric acid is very strong and will cause severe burns. Safety glasses, long rubber gloves, and clothing that covers as much of the body surface as possible are advised when working with it. Sulfuric acid burns are treated by immediate washing with water and bicarbonate of soda. The sulfuric acid is kept in a safety bottle made by permanently fitting a glass bottle with a screw top in a styrofoam-lined metal can.
A Pyrex pot containing the oil/alcohol/sulfuric acid solution is placed in the refluxing apparatus originally used for refluxing the material in alcohol. Pyrex
is substituted for the stainless-steel pot because of the reactive nature of the sulfuric acid. The rig is placed in the boiling water bath and refluxed for two hours. At the end of this time, the stew pot is placed in an ice-water bath and opened. The solution is poured
into an equal amount of water and extracted with petroleum ether, as was done in removing the ether- soluble oil from the alcohol extract solution. The ether solution is then poured into four volumes of water and gently inverted twenty-five times, releasing
the pressure each time. The layers are allowed to separate, the ether/oil layer is siphoned off and the water is discarded. The ether/oil solution is poured into four volumes of 5% bicarbonate of soda solution in water. It is mixed, then separated, and the either/oil
layer is siphoned off. The bicarbonate of soda solution is discarded and the previous step (washing with pure water) is repeated twice. The either is evaporated from the either/oil solution, as was done previously in the first purification using the stew pot apparatus. The pure ether is collected in the pan held in the colander, The oil now contains a much higher percentage of THC (determined by the amount of cannabidiol originally present). The THC is of the high-rotating isomeric form, and all of the toxins have been removed from the oil.
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CBD is mixed into many forms — powders, pills, oils and lotions. It can’t get you high, but some users say ingesting it or rubbing it on the skin helps with pain and other medical conditions. Most of those claims haven’t been vetted by the U.S. Food and Drug Administration, but GW Pharmaceuticals is in late-stage FDA clinical trials for a CBD-based drug for some epilepsy conditions.
“They have only one word: It’s illegal,” Hassan said.
Another application: it is perfect for salads, fish, also used in the manufacture of drying oil, varnishes and paints.
Loree Anne Paradise, a spokeswoman for Koster’s successor, Josh Hawley, would continue to “enforce the laws enacted by the legislature.”
Its CEO, Vince Sanders, said he’s confident he and those who sell them are on the right side of the law.
Hassan knows that nearby shops like Hodgson’s are still selling CBD. Meanwhile, he’s cut back from seven employees to four because of the loss of customers since he stopped.
“I’ve been on multiple MS drugs, and none of them are cures,” he said, “and I haven’t found any that help with my pain.”
Synonyms: Hemp Seed Oil, Cannabis sativa Seed Oil, Oleum cannabis
Read more here: http://www.kansascity.com/living/health ... rylink=cpy
Hemp oil shops crop up around KC area in uncertain legal landscape
Read more here: http://www.kansascity.com/living/health ... rylink=cpy
Shelf life: 0t 6 months to 1 year, depending on storage conditions. After opening it is recommended to keep it in the refrigerator.
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Regional hemp varieties in Ukraine: Glukhovsky 33, Glukhovsky 46, Dnieper single-homed 14, Zolotonoshsky 15, Zolotonoshsky monoecious 11 and others.
• Carbon monoxide. Emissions of carbon monoxide (toxic gas) exhaust gas using biodiesel were 50 percent
Synonyms: Hemp Seed Oil, Cannabis sativa Seed Oil, Oleum cannabis
Hemp is a cross-pollinated culture. The flowering period lasts 15-40 days. During flowering in the air there is a lot of pollen, which is carried by the wind for long distances.
Methods of application: Can be used both in the pure form for skin care, and as an additive, also suitable as a basis for massage. Hemp oil is added to soaps, shampoos, creams, lotions, tonics, masks for skin and hair, to lip balm.Synergy with: EM Roses, EM of the Pink Tree, EM of the incense gum - to prevent and combat the aging of the skin. Precautions: Oil has no contraindications. Not suitable for frying.
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Smith said he notified the Mission police chief before he started selling CBD. In downtown Kansas City, Brendon Hodgson named his shop The CBD Store and included in the storefront sign the green cross that’s often associated with medical marijuana dispensaries in states where those sort of stores are legal.
• Nitrogen oxides. The increase or decrease in nitrogen oxide emissions when using biodiesel depends on the type of engines and testing procedures. Emissions of nitrogen oxides using pure (100%) biodiesel in this test increased by 13 percent. However, the absence of sulfur in biodiesel makes it possible to use technologies to control the concentration of nitrogen oxides, which can not be used in a conventional diesel. Thus, emissions of nitrogen oxides in biodiesel using this type of fuel can be effectively managed and successfully eliminated
It’s derived from the cannabis plant, which most people know as marijuana. But CBD sellers call their version “hemp” because it comes from plants with little to no THC, the ingredient in marijuana that produces the “high” that recreational users are after.
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